Understanding Growth Hormone Secretion and Short Stature

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Spontaneous growth hormone secretion and plasma somatomedin-C in children of short stature.

We studied 17 short prepubertal children, aged 7.5 to 17.0 years (mean +/- SD: 11.7 +/- 2.4) more than 2.0 SD below the mean height for their age and of delayed bone age (M +/- SD: 8.1 +/- 2.3), to clarify their physiological GH secretory status. The mean concentration of GH (MCGH) was calculated and was compared with the subjects' GH responses to insulin and arginine tolerance tests (IATT) and...

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Growth hormone secretion provoked by insulin-induced hypoglycaemia in children of short stature.

The observation of Roth, Glick, Yalow, and Berson (1963) that growth hormone secretion is stimulated in response to insulin-induced hypoglycaemia has been used to identify the hypopituitary subject (Frantz and Rabkin, 1964; Kaplan, Abrams, Bell, Conte, and Grumbach, 1965). In this study, intravenous insulin-induced hypoglycaemia has been used to investigate growth hormone secretion in a group o...

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Growth hormone-induced nitrogen retention in children of short stature.

The decrease in urinary nitrogen excretion (i.e. increased nitrogen retention) following intramuscular injection of human growth hormone (HGH) has been used to differentiate hypopituitary dwarfism from other types of short stature. While small decreases can be demonstrated in almost all children who are given HGH, in the hypopituitary child the decrease is greater and more prolonged. Using a st...

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Comparison of Growth Hormone Treatment in Patients with Idiopathic Short Stature and Idiopathic Growth Hormone Deficiency

After recombinant human growth hormone (rhGH) was introduced in the treatment of patients with growth hormone deficiency (GHD) and idiopathic short stature (ISS), many studies have addressed the effect of GH treatment and changes in the height standard deviation score (SDS) after GH treatment. However, few studies comparing the effect of GH in Korean patients with idiopathic GHD and ISS have be...

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Effect of growth hormone treatment on children with idiopathic short stature and idiopathic growth hormone deficiency

PURPOSE There are inconsistencies in the results reported in a small number of previous studies into growth hormone (GH) treatment in Korean children with idiopathic short stature (ISS) and idiopathic growth hormone deficiency (IGHD). Thus, the authors retrospectively compared the effects of GH in ISS and IGHD. METHODS From the medical records of 26 ISS and 30 IGHD children, auxological and b...

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ژورنال

عنوان ژورنال: Open Journal of Endocrine and Metabolic Diseases

سال: 2016

ISSN: 2165-7424,2165-7432

DOI: 10.4236/ojemd.2016.61011